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May 14th, 2018 · post by Phil Chokeword · Make a comment

Danazol administered orally to pregnant rats from the 6th through the 15th day of gestation at doses up to 250 mg kg day 7 to 15 times the human dose did not result in drug-induced embryotoxicity or teratogenicity, nor difference in litter size, viability or weight of offspring compared to controls.

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danazol is known to bind to two steroid hormone carrier proteins sex hormone-binding globulin shbg , which binds androgens and estrogens; and transcortin corticosteroid-binding globulin , which binds progesterone and cortisol.

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